Jessica Drew (Earth-1600)

Jessica Drew (a.k.a. Arachnid) is a former S.H.I.E.L.D. agent who was actually a spy for Dodctor Octopus. She worked for him so he could find a cure for her illness, but was eventually caught by Spider-Man and was put in S.H.I.E.L.D. custody. She was later injected with a serum created by Octavius that gave her dangerous arachnid powers and exacted revenge on Spider-Man.