Scientific and Technological Advanced Research Laboratories (Earth-6531)

"How about, Scientific, and Technological Advanced Research Laboratories. Or S.T.A.R. Labs, for short."

- - Harrison Wells pitching the name's idea

The Scientific and Technological Advanced Research Laboratories, shortened S.T.A.R. Labs, was a research and development company based in Central City. Their greatest invention, however, the particle accelerator, was responsible for releasing the Big Bang Incident, a dark matter explosion upon the city that gave birth to numerous Metahumans, humans who gained powers thanks to the incident.

History
In 2000, physicists Harrison Wells and Tess Morgan devised the idea to create and open a laboratory in Central City, Ohio, where they could dedicate their research. While Harrison drew the initial sketches of the building, Tess suggested the name and the acronym.

Unfortunately for the couple, they weren't able to finish their dream plan when the time-travelling Reverse-Flash orchestrated a car crash that led to their deaths. The Reverse-Flash then took upon Wells' identity and the two's blueprints to finish their vision, albeit under his own dark purposes.