Ophelia Sarkissian (Earth-1955)

"We were a orphan. Little girls, all alone. The Reich gave us a home. Eight great houses. Twelve girls to a house. And in the end, the most determined... the most ambitious... the most aggressive... That girl would be Madame Hydra. All it cost was everything. My life, my humanity. But it doesn't matter anymore. I already have fallen into the abyss, and there is no way back from it."

- - Madame Hydra

Ophelia Sarkissian is a high-ranking member of HYDRA, both during World War II and in the present time, where she now serves as Arnim Zola's right-hand. Following the disappearance of Red Skull and the apprehension of Baron Zemo, Ophelia started a civil war over the leadership of HYDRA against Baron Strucker. She was later kidnapped by the Skrulls and replaced by one of their spies.