Jessica Drew (Earth-5430)

"This isn't a joke to me or a kid's game. This is--it's everything. You put that on. You make yourself a part of this. It means you're representing--it means-- You get it."

- - Spider-Woman

When the young Jessica Drew moved from England to an area with a large presence of Uranium, she became ill, prompting her father, Jonathan, to use on her a untested serum which possessed the blood of different spider species. The serum completely changed Jessica's body, transforming her in a superhuman with numerous powers. Becoming Spider-Woman, she was used by HYDRA as one of their guinea pigs, she had a change of heart after being guided by Hawkeye, then deciding to use her powers for good.