Madelyne Granger (Earth-5029)

"I only know my mission. My mission is to kill you. I do not wish to do this, but it is not my choice. So please, make it easier for both of us and take it like a man."

- Nemesis

Nemesis was raised by the ninjas of the Hand and has become one of Spider-Man's greatest enemies due to her inability to kill him, which greatly wounds her pride.