Elizabeth Brant (Earth-1969)

Elizabeth Brant was a secretary to the Daily Bugle publisher J. Jonah Jameson, before she became gravely ill due to exposure to the event horizon of a boom tube during Peridot's first invasion of Earth. She was taken in and looked after by Doctor Otto Octavius. It was here that she was was bitten in the neck by a genetically-altered spider composed of the DNA of a strange Symbiote. She is captured by  HYDRA who erase her memories, brainwash her, and recruit her as a HYDRA agent under the codename Arachne. She later leaves and becomes the heroine known as Spider-Woman. She fights to protect New York, later becoming a member of the Squadron Supreme.