Karen Kayman (Earth-444)

"Expectations? Oh, lord, don't lecture me on expectations. I'm the first born! I'm the only girl! For Christ's sake my father is Spider-Man! DON'T talk to ME about expecations."

-Arachnae to the Human Torch

Trivia

 * Archnae is the only female to inherit spider powers, and is the first of the symbiote generation (which ended the cross-species generation).
 * Arachnae is the first hero to surface, prior to the war between The Outlaws and the Spider-Men.