MacDonald Gargan (Earth-1600)

MacDonald "Mac" Gargan (a.k.a the Scorpion) was a private investigator who was secretly hired by J. Jonah Jameson to kill Spider-Man. He was given a compound of scorpion DNA (a natural predator of spiders) made based on Dr. Connors' research on cross-specie genetics, and became a humanoid scorpion.