Miranda Tate (Earth-5180)

Miranda Tate was the last CEO of Roxxon following Ferris Boyle's arrest, who focused on pharmaceutics in the hopes of creating a new drug to cure cancer, but was unable to so do after her business practices led the company to go bankrupt and close. Desperate to survive in Gotham City, Tate assumed the identity of Madame Masque and allied with former Roxxon scientist turned criminal Mister Freeze, offering to help cure Nora Fries in trade of his help.

Early Life
Following the arrest of Ferris Boyle after it was discovered he was doing illegal experimentation with guns and the attempted murder of Victor and Nora Fries, Roxxon was on the verge of falling down until Ferris' former business partner, Miranda Tate, stepped in to take helm of the company, and attempt to revitalize its corporate name.

For months she tried to change Roxxon's operations on fuels to shift into the pharmaceutics approach, namely, the cure for deadly diseases such as cancer, where she invested all of her money. However, because the drugs had horrid side-effects, it was never marketed or sold, causing Miranda and the entire company to lose assets and money, eventually crushing it, all the while she earned depths with the investor Sherman Fine.

Masque
Missing for days, Tate locked herself in her mansion, and fell in depression. She attempted to kill herself by jumping from the Pioneers' Bridge, but before she was able to do so, Miranda noticed an iceberg forming at Gotham's waters, and went to investigate. There, she found out the body of Mister Freeze, formerly Roxxon's scientist Victor Fries.