Nuclear weapon (Earth-8573)

A nuclear weapon is an explosive device that derives its destructive force from nuclear reactions, either fission or from a combination of fission and fusion reactions. Both bomb types release large quantities of energy from relatively small amounts of matter.

M4093 Hyperion nuclear delivery system
The Hyperion is a nuclear missile class featured on a number of warships of the UNSC Navy, such as Charon-class light frigates. It can destroy a CRS-class light cruiser with one strike, in the case its energy shields are down.

NOVA bomb
The NOVA bomb is the most powerful and destructive weapon ever created by humanity. Developed by Vice Admiral Michael Stanforth, it consists of nine warheads, which are encased within a lithium triteride shell. Once it is detonated, the NOVA boosts a yield "a hundred-fold". It is powerful enough to cause a nuclear devastation on an entire planet, and can also vaporize orbiting moons and spaceships with it.